Crosslinking, Labeling and Protein Modification
eMolecules DBCO-PEG6-NHS ester | Broadpharm |737.803 | C38H47N3O12 | 95.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 25mg | 698442844
DBCO-PEG6-NHS ester | Broadpharm |737.803 | C38H47N3O12 | 95.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 25mg | 698442844
Medchemexpress LLC DSPE PEG thiol | 25322-68-3 | 99.4% | 2000 (average) | 100 MG
DSPE-PEG-SH (MW 2000) is a thiol-terminated pegylated phospholipid used to introduce reactive thiol groups into lipid assemblies. The thiol group readily forms stable thioether linkages with maleimide and other electrophiles, enabling surface functionalization of liposomes and lipid nanoparticles for targeted delivery and conjugation of ligands such as peptides or antibodies.
- Thiol terminus enables covalent conjugation with maleimide groups.
- Incorporates into liposomes and lipid nanoparticles for surface functionalization.
- Amphipathic structure supports bilayer formation in aqueous systems.
- High purity (≈99.4%) suitable for research applications.
- Soluble in water and DMSO with warming and sonication.
eMolecules 864680-64-8 | Amino-PEG4-CH2CO2tBu | Broadpharm | MFCD28122943 | 307.387 | C14H29NO6 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCN | 1g | 254745387
Amino-PEG4-CH2CO2tBu | Broadpharm | 864680-64-8 | MFCD28122943 | 307.387 | C14H29NO6 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCN | 1g | 254745387
eMolecules 88299-47-2 | C11-PEG4-alcohol | Broadpharm304.471 | C17H36O4 | 98.000 | CCCCCCCCCCCOCCOCCOCCO | 1g | 303671286
C11-PEG4-alcohol | Broadpharm | 88299-47-2304.471 | C17H36O4 | 98.000 | CCCCCCCCCCCOCCOCCOCCO | 1g | 303671286
Biotium Insulin(E2-E3), CF647 conjugate, 0.1mg/mL
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have
Cayman Chemical GefItInIb-based PROTAC 3 1mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
eMolecules 1008402-47-8 | Bis-Mal-PEG3 | Broadpharm | MFCD22683311 | 494.501 | C22H30N4O9 | 98.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 200183412
Bis-Mal-PEG3 | Broadpharm | 1008402-47-8 | MFCD22683311 | 494.501 | C22H30N4O9 | 98.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 200183412
Medchemexpress LLC Methyltetrazine-PEG24-NHS ester | 00-00-0 | 99.3% | C64H111N5O29 | 10MG
Methyltetrazine-PEG24-NHS ester is a PEG24 linker bearing a methyltetrazine reactive moiety and an N-hydroxysuccinimide (NHS) activated ester. Provided as a dry research reagent, it is designed for bioconjugation and PROTAC linker synthesis, enabling rapid bioorthogonal ligation to trans-cyclooctene (TCO) derivatives and stable amide bond formation with primary amines. The long PEG24 spacer enhances aqueous solubility and provides flexibility between conjugated components.
- Enables rapid inverse electron-demand Diels-Alder (IEDDA) conjugation with TCO reagents.
- Provides an NHS ester for efficient coupling to primary amines.
- PEG24 spacer increases aqueous solubility and linker flexibility.
- High purity suitable for research applications.
- Supplied in mg-scale packages for small-scale conjugations.
- Intended for research use only and not for human therapeutic use.
Medchemexpress LLC FITC-PEG-NHS | 98.0% | 10 MG
FITC-PEG-NHS (average molecular weight 3,400) is a heterobifunctional fluorescent reagent composed of fluorescein (FITC) linked to polyethylene glycol (PEG) and terminated with an N-hydroxysuccinimide (NHS) ester. The NHS ester reacts with primary amines to form stable amide bonds, enabling conjugation of the FITC fluorophore to proteins, peptides, and other amine-containing biomolecules for labeling and imaging.
- Heterobifunctional fluorescent reagent with average molecular weight 3,400.
- NHS ester reactive toward primary amines to form stable amide bonds.
- Suitable for fluorescent labeling of proteins, peptides, and other amine-containing biomolecules.
- High supplied purity (98.0%).
- Available in lab-scale and larger package sizes to support research workflows.
Medchemexpress LLC DBCO-PEG6-NHS ester | 96.0% | 737.79 | 5 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent that contains an NHS ester. This NHS ester specifically reacts with primary amines, such as the side chains of lysine residues or aminosilane-coated surfaces, forming covalent bonds efficiently under neutral or slightly alkaline conditions. Additionally, DBCO-PEG6-NHS ester includes a DBCO group, which can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Reacts specifically with primary amines.
- Contains a DBCO group for SPAAC with Azide groups.
eMolecules 2364591-79-5 | DBCO-PEG1-amine | Broadpharm391.471 | C23H25N3O3 | 98.000 | NCCOCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 462125391
DBCO-PEG1-amine | Broadpharm | 2364591-79-5391.471 | C23H25N3O3 | 98.000 | NCCOCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 462125391
eMolecules Methyltetrazine-PEG7-DBCO | Broadpharm |826.948 | C44H54N6O10 | 97.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 25mg | 698442878
Methyltetrazine-PEG7-DBCO | Broadpharm |826.948 | C44H54N6O10 | 97.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 25mg | 698442878
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 500 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It is utilized in the synthesis of PROTAC SGK3 degrader-1.
- Polyethylene glycol (PEG)-based PROTAC linker
- Utilized in the synthesis of PROTAC SGK3 degrader-1
- Key component for protein degradation studies
- Potential inhibitor for SGK3 related research
Medchemexpress LLC DSPE-PEG-folate | 90.0% | 2000 g/mol (average) | C63H104N9O15P | 10 MG
DSPE-PEG-Folate is a PEGylated phospholipid supplied as a powder that presents folic acid as a targeting ligand for folate receptor-mediated delivery. It self-assembles into micelles or lipid bilayers and is intended for use in liposome formulation and targeted drug delivery research.
- Average molecular weight ~2000 g/mol.
- Purity 90.0%.
- Powder; light yellow to yellow.
- Soluble in DMSO at 50 mg/mL (requires ultrasonic).
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Forms micelles and lipid bilayers for receptor-targeted delivery.